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| Product Name | Ionomycin |
| Description |
Ca2+ ionophore |
| Purity | >98% |
| CAS No. | 56092-81-0 |
| Molecular Formula | C41H70O9 |
| Molecular Weight | 709.01 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 10 mM in ethanol and to 10 mM in DMSO |
| Source | Synthetic |
| Appearance | Colorless Solid |
| SMILES | C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)O |
| InChI | InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23 |
| InChIKey | PGHMRUGBZOYCAA-OJFQOPKISA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | Ionomycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-228) |
Biological Description
| Alternative Names | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid, Ionomycin calcium salt |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 6434517 |
| Scientific Background | Ionomycin is a calcium ionophore commonly used to increase intracellular calcium concentrations in experimental models. It is more selective than A23187 and is frequently employed in neuroscience to study calcium signaling, synaptic plasticity, and cytokine production in neural and glial cells. Its ability to stimulate intracellular calcium flux makes it a critical reagent for dissecting calcium-dependent processes in neurodegeneration and neuroinflammation. |
| References |
1. Holmes A.G. Watt M.J., Carey A.L. And Febbraio M.A. (2004) Metabolism. 53(11): 1492-1495. 2. Abramov A.Y., Duchen M.R. (2003) Cell Calcium. 33(2): 101-112. |
Product Images
Chemical structure of Ionomycin (SIH-228), a Ca2+ ionophore. CAS #: 56092-81-0. Molecular Formula: C41H70O9. Molecular Weight: 709.01 g/mol.
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Based on validation through cited publications.