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| Product Name | PK-11195 |
| Description |
Mitochondrial Benzodiazepine receptor ligand |
| Purity | >98% |
| CAS No. | 85532-75-8 |
| Molecular Formula | C21H21CIN2O |
| Molecular Weight | 352.86 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 75 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White Crystals |
| SMILES | CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl |
| InChI | InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 |
| InChIKey | RAVIZVQZGXBOQO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed R68- Possible risk of irreversible effects |
| Cite This Product | PK-11195 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-224) |
Biological Description
| Alternative Names | N-sec-Butyl-1-(2-chlorophenyl)-N-methyl-3-isoquinolinecarboxamide |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 1345 |
| Scientific Background | PK-11195 is an isoquinoline carboxamide that selectively binds to the translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor. It is widely used in neuroimaging to detect neuroinflammation via PET scans, particularly in conditions such as Alzheimer's disease, multiple sclerosis, and traumatic brain injury. PK-11195 serves as a biomarker for activated microglia, aiding in the assessment of neuroinflammatory states. |
| References |
1. Pike V.W., et al. (1993) Nucl Med & Bio. 20(4): 503-525. 2. Buck J.R., et al. (2011) J Nucl Med. 52(1): 107-114. |
Product Images
Chemical structure of PK-11195 (SIH-224), a Mitochondrial benzodiazepine receptor ligand. CAS #: 85532-75-8. Molecular Formula: C21H21CIN2O. Molecular Weight: 352.86 g/mol.
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