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| Product Name | PK-11195 |
| Description |
Mitochondrial Benzodiazepine receptor ligand |
| Purity | >98% |
| CAS No. | 85532-75-8 |
| Molecular Formula | C21H21CIN2O |
| Molecular Weight | 352.86 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 75 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White Crystals |
| SMILES | CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl |
| InChI | InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 |
| InChIKey | RAVIZVQZGXBOQO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed R68- Possible risk of irreversible effects |
| Cite This Product | PK-11195 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-224) |
Biological Description
| Alternative Names | N-sec-Butyl-1-(2-chlorophenyl)-N-methyl-3-isoquinolinecarboxamide |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 1345 |
| Scientific Background | PK-11195 is an isoquinoline carboxamide which binds selectively to the peripheral benzodiazepine receptor (PBR). It has a high affinity for the PBR in all species (1). It has also been successfully used in PET scans to visualize brain inflammation in patients with neuronal damage (2). |
| References |
1. Pike V.W., et al. (1993) Nucl Med & Bio. 20(4): 503-525. 2. Buck J.R., et al. (2011) J Nucl Med. 52(1): 107-114. |
Product Images
Chemical structure of PK-11195 (SIH-224), a Mitochondrial benzodiazepine receptor ligand. CAS #: 85532-75-8. Molecular Formula: C21H21CIN2O. Molecular Weight: 352.86 g/mol.
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