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| Product Name | Urolithin A |
| Description |
Mitophagy inducer |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 1143-70-0 |
| Molecular Formula | C13H8O4 |
| Molecular Weight | 228.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | May be dissolved in DMSO (50 mg/ml) |
| Source | Synthetic |
| Appearance | Pale-yellow powder |
| SMILES | OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1 |
| InChI | InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H |
| InChIKey | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Irritant GHS07 Hazard Statements, H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Precautionary Statement Codes, P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 |
| Cite This Product | Urolithin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-610) |
Biological Description
| Alternative Names | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin |
| Research Areas | Alzheimer's Disease, Cancer, Neurodegeneration, Neuroscience, Parkinson's Disease |
| PubChem ID | 5488186 |
| Scientific Background | Urolithin A is a gut microbiota-derived metabolite of dietary ellagitannins, known for its ability to induce mitophagy and improve mitochondrial health. In neurodegenerative disease research, Urolithin A has demonstrated neuroprotective effects by promoting mitophagy and suppressing NLRP3 inflammasome activation in microglial cells. These mechanisms are particularly relevant in models of Parkinson’s disease and Alzheimer’s disease, where mitochondrial dysfunction and neuroinflammation are key pathological features. Urolithin A also enhances T cell function ex vivo, suggesting broader implications for immune modulation in neurodegenerative conditions. |
| References |
1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:1152 2.Ryu D., et al. 2016 Nat. Med. 22:879 3.Qiu J., et al. 2022 Neuropharmacology 207:108963 4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744 5.Denk D., et al. 2022 Immunity. 55:2059 |
Product Images
Chemical structure of Urolithin A (SIH-610), a Mitophagy inducer. CAS #: 1143-70-0. Molecular Formula: C13H8O4 . Molecular Weight: 228.2 g/mol.
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