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| Product Name | Mifepristone (RU486) |
| Description |
Glucocorticoid antagonist |
| Purity | >98% |
| CAS No. | 84371-65-3 |
| Molecular Formula | C29H35NO2 |
| Molecular Weight | 429.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO, and to 50 mM in ethanol |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O |
| InChI | InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3) |
| InChIKey | VKHAHZOOUSRJNA-GCNJZUOMSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R60- May impair fertility R61- May cause harm to the unborn child Hazard Phrases: H360 Precautionary Phrases: P201-P308 + P313 |
| Cite This Product | Mifepristone (RU486) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-211) |
Biological Description
| Alternative Names | (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one, RU486, RU 38486 |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 55245 |
| Scientific Background | Mifepristone is a progesterone receptor antagonist used as an abortifacient. It is also an antiglucocorticoid and an antiandrogen. Its relative binding affinity at the progesterone receptor is twice that of progesterone, its affinity at the glucocorticoid receptor is 3x that of dexamethasone, and more than 10 times that of cortisol (1). |
| References | 1. Heikinheim O., Kekkonen R. and Lahteenmaki P. (2003) Contraception. 68(6): 421-426. |
Product Images
Chemical structure of Mifepristone (RU486) (SIH-211), a Glucocorticoid antagonist. CAS #: 84371-65-3. Molecular Formula: C29H35NO2 . Molecular Weight: 429.6 g/mol.
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