Myriocin (ISP-1)

Palmitoyltransferase inhibitor

Catalog No. SIH-233

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CAS No. 35891-70-4
Molecular Formula C21H39NO6
SKU: SIH-233 Categories: ,

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SIH-233_Myriocin_ISP-1_Chemical_Structure.png
Product Name Myriocin (ISP-1)
Description

Palmitoyltransferase inhibitor

Purity >98%
CAS No. 35891-70-4
Molecular Formula C21H39NO6
Molecular Weight 401.54
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 2 mg/ml of methanol, DMSO (25 mg/ml; heat briefly in boiling water bath) or in dilute base (5 mg/ml; 50 mM NaOH)
Source Synthetic
Appearance Off-White Solid
SMILES CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
InChI InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
InChIKey ZZIKIHCNFWXKDY-GNTQXERDSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label wherepossible)
Risk Phrases:
R22- Harmful if swallowed
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product Myriocin (ISP-1) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-233)

Biological Description

Alternative Names (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid
Research Areas Apoptosis, Cancer
PubChem ID 6438394
Scientific Background Myriocin, or ISP-1, is an atypical amino acid and an antibiotic. It is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis (1). It was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. It also possesses immunosuppressant activity (2).
References 1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641.
2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.

Product Images

<p>Chemical structure of Myriocin (ISP-1) (SIH-233), a Blocks sphingolipid biosynthesis. CAS #: 35891-70-4. Molecular Formula: C21H39NO6. Molecular Weight: 401.54 g/mol.</p>

Chemical structure of Myriocin (ISP-1) (SIH-233), a Blocks sphingolipid biosynthesis. CAS #: 35891-70-4. Molecular Formula: C21H39NO6. Molecular Weight: 401.54 g/mol.

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