PMA

Name: PMA
SKU: SIH-508
Availability: InStock

PKC kinase activator

Catalog No. SIH-508

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CAS No.	16561-29-8
Molecular Formula	C36H58O8

SKU: SIH-508 Categories: Activator, Small Molecules

Product Name	PMA
Description	PKC kinase activator
Purity	99% (TLC)
CAS No.	16561-29-8
Molecular Formula	C₃₆H₅₈O₈
Molecular Weight	616.8
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Activator
Solubility	Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers
Source	Synthetic
Appearance	Colorless amorphous film or foam
SMILES	O=C(OC41C(C2/C=C(/CO)CC3(O)C(O)C(=C/C3C2(O)C(C)C1OC(=O)CCCCCCCCCCCCC)C)C4(C)C)C
InChI	InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,
InChIKey	PHEDXBVPIONUQT-RGYGYFBISA-N
Safety Phrases	Classification: Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. Precautionary statements: P264 Wash skin thoroughly after handling. P280 Wear protective gloves. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse.
Cite This Product	PMA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-508)

Alternative Names	Phorbol 12-myristate 13-acetate
Research Areas	Cell Signaling
PubChem ID	27924
Scientific Background	PMA (Phorbol 12-myristate 13-acetate) is a phorbol ester. It is used experimentally as a reversible protein kinase C (PKC) activator. It has been shown to be a potent tumor promoter.
References	1. Murphy T. V., Prountzos C., Kotsonis P., Iannazzo L., & Majewski H. (1999). Euro.J. Pharm. 381(1): 77–84. 2. Castagna M., et al. (1982) J. Biol. Chem. 257(13): 7847–7851.

Chemical structure of PMA (SIH-508), a PKC kinase activator. CAS #: 16561-29-8. Molecular Formula: C36H58O8. Molecular Weight: 616.8 g/mol.

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