TTR – Transthyretin

StressMarq Biosciences is a leading provider of high-quality fibrillar, oligomeric, and monomeric protein preparations—including alpha synuclein, tau, amyloid beta, TDP-43, SOD1, TTR and more—designed to support cutting-edge neurodegenerative disease research. With a focus on pathology-inducing protein aggregates, our products support the development of robust disease models and accelerate drug discovery for conditions such as Alzheimer’s, Parkinson’s, and ALS. StressMarq is committed to scientific excellence— empowering researchers worldwide with tools that accelerate discovery and translational research.

Transthyretin (TTR) Filaments & Monomers

Transthyretin (TTR) is a tetrameric transport protein primarily involved in the delivery of thyroxine and retinol-binding protein. Misfolding of TTR is associated with systemic and hereditary amyloidoses, including familial amyloid polyneuropathy (FAP) and senile systemic amyloidosis (SSA). Amyloidogenic mutations such as L55P and Y78F destabilize the native tetramer, promoting dissociation and aggregation into insoluble fibrils. These aggregates can be quantified using turbidity assays and are implicated in tissue damage and organ dysfunction.

StressMarq Biosciences offers a selection of mutant TTR protein aggregates. Our reagents support research into protein misfolding disorders and help accelerate the development of disease models and targeted treatments.

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StressMarq manufactures L55P and Y78F TTR filaments and monomer constructs for use in neurodegenerative disease research.

TEM of Human Recombinant Transthyretin L55P Variant Protein Filaments (SPR-464)

TEM of Human Recombinant Transthyretin L55P Mutant Filaments (SPR-464)

Turbidity Assay shows increased turbidity in Human Recombinant Transthyretin L55P Variant Protein Filaments (SPR-464)

Turbidity Assay shows increased turbidity in Human Recombinant Transthyretin L55P Mutant Filaments (SPR-464)

 

 

 

 

 

 

 

 

 

 

 

 

 

1. Lashuel, H.A. et al. (1999) Biochem. 38(41):13560-73.
2. Terazaki, H. et al. (2006) Lab. Investigation. 86, 23-31.
3. Robinson, L. Z., Reixach, N. (2014) Biochem. 53(41):6496-510.

Product Citations

StressMarq’s proteins for neurodegenerative disease research have been cited in many peer-reviewed scientific journals. 

  • Parkinson disease-associated toxic exposures selectively upregulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons. Clark, K. A. et al. Mol Biol Cell. Jan 2025.
    • Catalog# SPR-464: Human Recombinant Transthyretin (TTR) L55P Variant Filaments

Supplemental Learning Materials

 

Technical Support Resources

Selected Publications from the StressMarq Blog

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