Products

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

    5.00 out of 5 based on 2 customer ratings
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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils: ATTO 488

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs: ATTO 488

    Catalog No. SPR-329-A488

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
    Tags ATTO 488
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    SPR-329-A488_Tau-Protein-Protein-TEM-1.png
    TEM of ATTO conjugated tau pre-formed fibrilsThioflavin T assay of ATTO-488 conjugated tau fibrils

  • Tau dGAE (297-391) C322A Mutant Pre-formed Fibrils

    Human Recombinant Tau dGAE (297-391) C322A Mutant PFFs

    Catalog No. SPR-462

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    Expression System E. coli
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    SPR-462_Tau-Preformed-Fibrils-Protein-TEM-1.png
    TEM of Active Human Recombinant Truncated Tau (AA297-391) (dGAE C322A) Protein Pre-formed Fibrils (SPR-462)

  • Tau dGAE (297-391) Pre-formed Fibrils

    Human Recombinant Tau dGAE (297-391) PFFs

    Catalog No. SPR-461

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    Expression System E. coli
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    SPR-461_Tau-Preformed-Fibrils-Protein-TEM-1.png
    TEM of Active Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Pre-formed Fibrils (SPR-461)

  • Tau (K18) P301L Mutant Pre-formed Fibrils

    Human Recombinant Tau (K18) P301L Mutant PFFs

    Catalog No. SPR-330

    5.00 out of 5 based on 2 customer ratings
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    Expression System E. coli
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    SPR-330_Tau-Preformed-Fibrils-Protein-IHC-1.png
    Comparison of AT8 (pSer202/pThr205) tau inclusions in P301L mice injected with K18 PFFs and negative control.TEM of recombinant Tau (K18), P301L mutant Pre-formed Fibrils (PFFs)TEM of recombinant Tau (K18), P301L mutant Pre-formed Fibrils (PFFs)Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau Pre-formed fibrils (SPR-330). Tau Pre-formed fibrils (SPR-330) seed the formation of new tau fibrils when combined with tau monomers (SPR-327)SDS-PAGE of ~15 kDa Human Tau Protein K18/P301L Pre-formed Fibrils (SPR-330)

  • Alpha Synuclein N-Terminal Acetylated Pre-formed Fibrils

    Human Recombinant N-Terminal Acetylated Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-332

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
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    SKU: SPR-332 Category:

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    SPR-332_N-Terminal-Acetylated-Alpha-Synuclein-Fibril-Protein-TEM-1.png
    TEM of N-acetylated alpha synuclein PFFsThioflavin T Seeding Assay of N-Terminal Acetylated Alpha Synuclein Pre-formed Fibrils (SPR-332)

  • Gamma Synuclein Pre-formed Fibrils

    Human Recombinant Gamma Synuclein PFFs (Type 1)

    Catalog No. SPR-459

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    Expression System E. coli
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    SPR-459_Gamma-Synuclein-Preformed-Fibrils-Protein-TEM-1.png
    Thioflavin T assay shows increased fluorescence when gamma synuclein fibrils and monomers are combined.

  • Beta Synuclein Pre-formed Fibrils

    Human Recombinant Beta Synuclein PFFs (Type 1)

    Catalog No. SPR-457

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    Expression System E. coli
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    SPR-457_Beta-Synuclein-Preformed-Fibrils-Protein-TEM-1.png
    Primary rat hippocampal neurons treated with human beta synuclein Pre-formed fibrils (SPR-457)Thioflavin T Assay of Alpha and Beta Synuclein Cross-Seeding

  • SOD1 Pre-formed Fibrils

    Human Recombinant Superoxide Dismutase 1 (SOD1) PFFs

    Catalog No. SPR-470

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    Expression System E. coli
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    SPR-470_SOD1-Protein-TEM-2.png
    TEM of human SOD1 pre-formed fibrils (PFFs) (SPR-470)Thioflavin T assay of SOD1 fibrils and monomers

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs (Baculovirus/Sf9)

    Catalog No. SPR-471

    5.00 out of 5 based on 1 customer rating
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    Expression System Baculovirus (Sf9)
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    SPR-471_Tau-Protein-TEM-1.png
    Thioflavin T assay of tau pre-formed fibrils (SPR-471)Mass spectrometry analysis of tau PFFs (SPR-471)