HSP Modulators: JG-98
Heat Shock Protein 70/HSP70 Inhibitor
Molecular Formula: C24H21Cl2N3OS3
Molecular Weight: 534.53 g/mol
Research Areas: Cancer Research, Heat Shock, Apoptosis
Alternative Names: 3-benzyl-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
JG-98 is an allosteric Heat shock protein 70 (HSP70) inhibitor. It binds within the nucleotide binding domain of HSP70, adjacent to ATP/ADP binding pocket. JG-98 blocks HSC70-Bag1 interactions both in vitro and in vivo. It is an active anti-cancer compound. JG-98 inhibits growth of MCF-7 and MDA-MB-231 breast cancer cells, with EC50s of 400 nM. Target identification in multiple myeloma cells showed that it targets mortalin and Hsp60. Jg-98 destabilizes oncoproteins, including Akt and Raf-1. It reduces apoptosis.
- Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013;4(11).