Proteins

  • Transthyretin (TTR) Y78F Variant Filaments

    Human Recombinant Transthyretin (TTR) Y78F Variant Filaments

    Catalog No. SPR-465

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    SPR-465_TTR-Protein-Filaments-Protein-Turbidity-Assay-1.png

  • Transthyretin (TTR) Y78F Variant Monomers

    Human Recombinant Transthyretin (TTR) Y78F Variant Monomers

    Catalog No. SPR-452

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    SPR-452_Transthyretin-Protein-SDS-PAGE-1.png

  • MOLECULAR SIGNATURE® 3,5-Dibromo-tyrosine BSA Conjugate (Discontinued)

    3,5-Dibromo-tyrosine conjugated to Bovine Serum Albumin (BSA)

    Catalog No. SPR-212

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    Expression System Synthetic
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    SPR-212_3-5-Dibromo-tyrosine-BSA-Conjugate-Protein-Dot-Blot-1.png

  • MOLECULAR SIGNATURE® 4-Hydroxy-2-hexenal BSA Conjugate

    Bovine Serum Albumin (BSA) modified with 4-Hydroxy-2-hexenal (4-HHE)

    Catalog No. SPR-210

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    Expression System Synthetic
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    SPR-210_4-Hydroxy-2-hexenal-BSA-Conjugate-Protein-Western-Blot-1.png

  • MOLECULAR SIGNATURE® 4-Hydroxynonenal BSA Conjugate

    Bovine Serum Albumin (BSA) modified with 4-Hydroxy nonenal (4-HNE)

    Catalog No. SPR-211

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    Expression System Synthetic
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    SPR-211_4-Hydroxynonenal-BSA-Conjugate-Protein-Western-Blot-1.png

  • MOLECULAR SIGNATURE® Acrolein BSA Conjugate

    Bovine Serum Albumin (BSA) modified with Acrolein

    Catalog No. SPR-206

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    Expression System Synthetic
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    SPR-206_Acrolein-BSA-Conjugate-Protein-Western-Blot-1.png

  • AHA1 Protein

    Human Recombinant AHA1 Protein

    Catalog No. SPR-300

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    Expression System E. coli
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    SPR-300_AHA1_Protein_SDS-Page.png

  • AHA1 Protein

    Human Recombinant AHA1 Protein

    Catalog No. SPR-309

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    SPR-309_AHA1-Protein-SDS-Page-1.png

  • AHA1 Protein (Discontinued)

    Mouse Recombinant AHA1 Protein

    Catalog No. SPR-311

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  • AHA1 Protein (Discontinued)

    Yeast Recombinant AHA1 Protein

    Catalog No. SPR-314

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  • AHA2 Protein (Discontinued)

    Human Recombinant AHA2 Protein

    Catalog No. SPR-312

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  • AHA2 Protein (Discontinued)

    Mouse Recombinant AHA2 Protein

    Catalog No. SPR-313

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  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 1)

    Catalog No. SPR-321

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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-322

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    Expression System E. coli
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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).