Neurodegeneration

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  • Tau-383 (0N4R) Wild-Type Monomers

    Human Recombinant Tau-383 (0N4R) Wild-Type Monomers

    Catalog No. SPR-509

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    Expression System E. coli
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    SPR-509_Tau-383-0N4R-Wild-Type-Monomers-Protein-SDS-PAGE-1.png
    THT Assay of Tau-383 (ON4R) Wild-Type Monomers (SPR-509)

  • Tau-383 (0N4R) Wild-Type Pre-formed Fibrils

    Human Recombinant Tau-383 (0N4R) Wild-Type PFFs

    Catalog No. SPR-510

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    Expression System E. coli
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    SPR-510_Tau-383-0N4R-Wild-Type-Pre-formed-Fibrils-Protein-TEM-1.png
    Thioflavin T assay of Tau-383 (0N4R) Wild-Type Pre-formed Fibrils Protein (SPR-510)Sedimentation assay of Tau-383 (0N4R) Wild-Type Pre-formed Fibrils Protein (SPR-510)AFM of Tau-383 (0N4R) Wild-Type Pre-formed Fibrils Protein (SPR-510)SDS-PAGE of Tau-383 (0N4R) Wild-Type Pre-formed Fibrils Protein (SPR-510)

  • Tau-412 (1N4R) Wild-Type Monomers

    Human Recombinant Tau-412 (1N4R) Wild-Type Monomers

    Catalog No. SPR-511

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    Expression System E. coli
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    SPR-511_Tau-412-1N4R-Wild-Type-Monomers-Protein-SDS-PAGE-1.png
    Thioflavin T assay of Tau-412 (1N4R) Wild-Type Monomers Protein (SPR-511)

  • Tau-412 (1N4R) Wild-Type Pre-formed Fibrils

    Human Recombinant Tau-412 (1N4R) Wild-Type PFFs

    Catalog No. SPR-512

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    Expression System E. coli
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    SPR-512_Tau-412-1N4R-Wild-Type-Pre-formed-Fibrils-Protein-TEM-1.png
    Thioflavin T assay of Tau-412 (1N4R) Wild-Type Pre-formed Fibrils Protein (SPR-512)Sedimentation assay of Tau-412 (1N4R) Wild-Type Pre-formed Fibrils Protein (SPR-512)AFM of Tau-412 (1N4R) Wild-Type Pre-formed Fibrils Protein (SPR-512)SDS-PAGE of Tau-412 (1N4R) Wild-Type Pre-formed Fibrils Protein (SPR-512)

  • Tau-430 (2N4R) P290S Mutant Monomers

    Mouse Recombinant Tau-430 (2N4R) P290S Mutant Monomers

    Catalog No. SPR-474

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    Expression System E. coli
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    SPR-474_Tau-Protein-Protein-SDS-PAGE-1.png

  • Tau-430 (2N4R) P290S Mutant Pre-formed Fibrils

    Mouse Recombinant Tau-430 (2N4R) P290S Mutant PFFs

    Catalog No. SPR-475

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    Expression System E. coli
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    SPR-475_Tau-Protein-Protein-TEM-1.png

  • Tau-441 (2N4R) P301S Mutant Filaments

    Human Recombinant Tau-441 (2N4R) P301S Mutant Filaments

    Catalog No. SPR-463

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    Expression System E. coli
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    SPR-463_Tau-Protein-Filaments-Protein-TEM-1.png
    TEM of Human Recombinant Tau Protein Filaments (SPR-463)TEM of Human Recombinant Tau Protein Filaments (SPR-463)

  • Tau-441 (2N4R) P301S Mutant Monomers

    Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers

    Catalog No. SPR-327

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    Expression System E. coli
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    SPR-327_Tau-Protein-Monomer-SDS-PAGE-1.png
    Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in active tau monomers (SPR-327). A greater increase in fluorescence is seen when 50 μM active monomer (SPR-327) is combined with 10 μM of active fibrils (SPR-329 or SPR-330), as the active fibrils seed the formation of new fibrils from the pool of active monomers.

  • Tau-441 (2N4R) P301S Mutant Monomers

    Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (Baculovirus/Sf9)

    Catalog No. SPR-473

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    Expression System Baculovirus (Sf9)
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    SPR-473_Tau-Protein-SDS-PAGE-1.png
    Thioflavin T assay of tau pre-formed fibrils (SPR-473)Mass spectrometry analysis of tau monomers (SPR-473)

  • Tau-441 (2N4R) P301S Mutant Monomers

    Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)

    Catalog No. SPR-515

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    Expression System Chinese Hamster Ovary (CHO)
    Tags N-term histidine tag & TEV site
    SKU: SPR-515 Category:

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    SPR-515_Tau-441-2N4R-P301S-Mutant-Monomers-CHO-expressed-N-glycosylated-Protein-SDS-Page-1.png
    SDS-PAGE of SPR-515 glycosylation.Mass spectrometry of human P301S Tau 2N4R monomers expressed using CHO cells (SPR-515).Mass spectrometry of human P301S Tau 2N4R monomers expressed using CHO cells (SPR-515).Dot Blot of purified hTau (2N4R) P301S monomers (SPR-515)

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs

    Catalog No. SPR-329

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    Expression System E. coli
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    SPR-329_Tau-Protein-Peformed-Fibrils-TEM-1.png
    TEM of recombinant Tau441 (2N4R), P301S mutant Pre-formed Fibrils (PFFs)Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) when tau Pre-formed fibrils (SPR-329) are combined with tau monomers (SPR-327). The Pre-formed fibrils seed the formation of new fibrils from a pool of monomers.SDS-PAGE of ~67 kDa Human Tau 2N4R P301S Pre-formed Fibrils (PFFs)

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs (Baculovirus/Sf9)

    Catalog No. SPR-471

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    Expression System Baculovirus (Sf9)
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    SPR-471_Tau-Protein-TEM-1.png
    Thioflavin T assay of tau pre-formed fibrils (SPR-471)Mass spectrometry analysis of tau PFFs (SPR-471)

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs (CHO-expressed, N-glycosylated)

    Catalog No. SPR-516

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    Expression System Chinese Hamster Ovary (CHO)
    Tags N-term histidine tag & TEV site
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    SPR-516_Tau-441-2N4R-P301S-Mutant-Pre-formed-Fibrils-CHO-expressed-N-glycosylated-Protein-TEM-1.png
    Native-PAGE of CHO-expressed Tau monomers (SPR-515) & fibrils (SPR-516)ThT fluorescence (excitation at 450nm, emission at 485nm) of CHO-expressed Tau monomers (SPR-515) and pre-formed fibrils (SPR-516)SDS-PAGE of SPR-516 glycosylation.Mass spectrometry of human P301S Tau 2N4R monomers expressed using CHO cells (SPR-515).Mass spectrometry of human P301S Tau 2N4R monomers expressed using CHO cells (SPR-515).Dot Blot of purified hTau (2N4R) P301S monomersRepresentative TEM image of Cho-expressed Tau 2N4R P301S Pre-Formed Fibrils (SPR-516)Atomic force microscopy analysis of Cho-expressed Tau 2N4R P301S Pre-Formed Fibrils (SPR-516)

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils: ATTO 488

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs: ATTO 488

    Catalog No. SPR-329-A488

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    Expression System E. coli
    Tags ATTO 488
    SKU: SPR-329-A488 Category:

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    SPR-329-A488_Tau-Protein-Protein-TEM-1.png
    TEM of ATTO conjugated tau pre-formed fibrilsThioflavin T assay of ATTO-488 conjugated tau fibrils

  • Tau-441 (2N4R) Wild-Type Monomers

    Human Recombinant Tau-441 (2N4R) Wild-Type Monomers

    Catalog No. SPR-479

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    Expression System E. coli
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    SPR-479_Tau-Protein-SDS-PAGE-1.png
    Thioflavin T assay of Tau Wild-Type fibrils (SPR-480) and monomers (SPR-479)

  • Tau-441 (2N4R) Wild-Type Monomers

    Human Recombinant Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9)

    Catalog No. SPR-496

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    Expression System Baculovirus (Sf9)
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    SPR-496_Tau-441-2N4R-Wild-Type-Monomers-Baculovirus-Sf9-Protein-SDS-PAGE-1
    Dot Blot of Human Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9) Protein (SPR-496)Mass Spec Table of Human Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9) Protein (SPR-496)