Neuroscience

  • (R,S)-Niguldipine HCl

    Ca2+ channel blocker

    Catalog No. SIH-319

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    CAS No. 119934-51-9
    Molecular Formula C36H39N3O6•HCl
    SKU: SIH-319 Categories: ,

    SIH-319_R-Niguldipine_HCl_Chemical_Structure.png

  • 2-APB

    TRP blocker

    Catalog No. SIH-316

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    CAS No. 524-95-8
    Molecular Formula C14H16BNO
    SKU: SIH-316 Categories: ,

    SIH-316_2-APB_Chemical_Structure.png

  • A-803467

    NaV1.8 blocker

    Catalog No. SIH-304

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    CAS No. 944261-79-4
    Molecular Formula C19H16ClNO4
    SKU: SIH-304 Categories: ,

    SIH-304_A-803467_Chemical_Structure.png

  • A-967079

    TRPA1 blocker

    Catalog No. SIH-301

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    CAS No. 1170613-55-4
    Molecular Formula C12H14FNO
    SKU: SIH-301 Categories: ,

    SIH-301_A-967079_Chemical_Structure.png

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

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    Expression System E. coli
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    SKU: SPR-316 Category:

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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 1)

    Catalog No. SPR-321

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    Expression System E. coli
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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-322

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    Expression System E. coli
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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).

  • Amlodipine

    L-type Ca channel blocker

    Catalog No. SIH-315

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    CAS No. 111470-99-6
    Molecular Formula C20H25ClN2O5•C6H5SO3H
    SKU: SIH-315 Categories: ,

    SIH-315_Amlodipine_Chemical_Structure.png

  • AP-18

    TRPA1 blocker

    Catalog No. SIH-310

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    CAS No. 55224-94-7
    Molecular Formula C11H12ClNO
    SKU: SIH-310 Categories: ,

    SIH-310_AP-18_Chemical_Structure.png

  • Astemizole

    Herg channel blocker

    Catalog No. SIH-302

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    CAS No. 68844-77-9
    Molecular Formula C28H31FN4O
    SKU: SIH-302 Categories: ,

    SIH-302_Astemizole_Chemical_Structure.png

  • BC-11-38

    Inhibitor

    Catalog No. SIH-373

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    CAS No. 686770-80-9
    Molecular Formula C15H16N2OS2
    SKU: SIH-373 Categories: ,

    SIH-373_BC-11-38_Chemical_Structure.png

  • BCTC

    TRPV1 blocker

    Catalog No. SIH-307

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    CAS No. 393514-24-4
    Molecular Formula C20H25ClN4O
    SKU: SIH-307 Categories: ,

    SIH-307_BCTC_Chemical_Structure.png

  • Bexarotene

    Retinoid RXR agonist

    Catalog No. SIH-535

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    CAS No. 153559-49-0
    Molecular Formula C24H28O2
    SKU: SIH-535 Categories: ,

    SIH-535-Bexarotene-Chemical-Structure.png

  • BRL-50481

    PDE7 inhibitor

    Catalog No. SIH-374

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    CAS No. 433695-36-4
    Molecular Formula C9H12N2O4S
    SKU: SIH-374 Categories: ,

    SIH-374_BRL-50481_Chemical_Structure.png

  • BzATP

    Prototypic P2X7 receptor agonist

    Catalog No. SIH-420

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    CAS No. 112898-15-4
    Molecular Formula C24H24N5O15P3•C18H45N3
    SKU: SIH-420 Categories: ,

    SIH-420_BzATP_Chemical_Structure.png