Products

  • bis-BHT

    Phenolic antioxidant

    Catalog No. SIH-154

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    CAS No. 118-82-1
    Molecular Formula C29H44O2
    SKU: SIH-154 Categories: ,

    SIH-154_bis-BHT_Chemical_Structure.png

  • 6BIO

    PDK1 kinase inhibitor

    Catalog No. SIH-422

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    CAS No. 667463-62-9
    Molecular Formula C16H10BrN3O2
    SKU: SIH-422 Categories: ,

    SIH-422_6BIO_Chemical_Structure.png

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

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    Expression System E. coli
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    SKU: SPR-316 Category:

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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 1)

    Catalog No. SPR-321

    5.00 out of 5 based on 1 customer rating
    Reviews (1)
    Expression System E. coli
    Tags No tag
    SKU: SPR-321 Category:

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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Pre-formed Fibrils: ATTO 594

    Human Recombinant Alpha Synuclein PFFs: ATTO 594 (Type 1)

    Catalog No. SPR-322-A594

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    Expression System E. coli
    Tags ATTO 594
    SKU: SPR-322-A594 Category:

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    SPR-322-A594_Alpha-Synuclein-Protein-Protein-TEM-1.png
    Thioflavin T Assay for SPR-322-A594Human iPSC-derived neurons seeded with ATTO594 labelled alpha synuclein PFFs (SPR-322-A594)TEM of ATTO conjugated alpha syuclein pre-formed fibrils

  • Alpha Synuclein Monomers

    Mouse Recombinant Alpha Synuclein Monomers (Type 1)

    Catalog No. SPR-323

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    Expression System E. coli
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    SPR-323_Alpha-Synuclein-Protein-IHC-1.png
    Mouse alpha Synuclein monomers (SPR-323) form new alpha synuclein fibrils through the seeding activity of Type 1 alpha synuclein pre-formed fibrils (SPR-324) as shown by increased fluorescence intensity by Thioflavin T over time.SDS-Page of Mouse Recombinant Alpha Synuclein Protein Monomer (SPR-323)

  • Alpha Synuclein A53T Mutant Monomers

    Human Recombinant Alpha Synuclein A53T Mutant Monomers (Type 1)

    Catalog No. SPR-325

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    Expression System E. coli
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    SKU: SPR-325 Category:

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    SPR-325_A53T-Alpha-Synuclein-Monomer-Protein-SDS-PAGE-1.png
    Thioflavin T emission curves show increased fluorescence (correlated to alpha synuclein aggregation) when A53T alpha synuclein Pre-formed fibrils (SPR-326) are combined with A53T alpha synuclein monomers (SPR-325). The Pre-formed fibrils seed the formation of new fibrils from a pool of monomers.Cisbio Total Alpha Synuclein AssayCisbio Alpha Synuclein Aggregation Assay

  • Alpha Synuclein A53T Mutant Pre-formed Fibrils

    Human Recombinant Alpha Synuclein A53T Mutant PFFs (Type 1)

    Catalog No. SPR-326

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    Expression System E. coli
    Tags No tag
    SKU: SPR-326 Category:

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    SPR-326_A53T-Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-2.png
    Thioflavin T emission curves show increased fluorescence (correlated to alpha synuclein aggregation) when A53T alpha synuclein Pre-formed fibrils (SPR-326) are combined with A53T alpha synuclein monomers (SPR-325). The Pre-formed fibrils seed the formation of new fibrils from a pool of monomers.ICC/IF of human A53T Alpha Synuclein Preformed Fibrils Protein (SPR-326)ICC/IF of human A53T Alpha Synuclein Preformed Fibrils Protein (SPR-326)ICC of primary rat neurons treated with A53T alpha synuclein PFFs show Lewy body inclusion formation.Cisbio Alpha Synuclein Aggregation AssayCisbio Total Alpha Synuclein AssayLDH assay shows effect of A53T alpha synuclein PFFs on mouse primary neuronsMTT assay effects of A53T alpha synuclein PFFs on mouse primary neuronsTEM of A53T alpha synuclein pre-formed fibrils (SPR-326).

  • Tau (K18) P301L Mutant Monomers

    Human Recombinant Tau (K18) P301L Mutant Monomers

    Catalog No. SPR-328

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    Expression System E. coli
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    SPR-328_Tau-Protein-Monomer-SDS-PAGE-1.png
    Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) in tau K18 P301L monomers (SPR-328) over time.

  • Tau (K18) P301L Mutant Pre-formed Fibrils

    Human Recombinant Tau (K18) P301L Mutant PFFs

    Catalog No. SPR-330

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    Expression System E. coli
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    SKU: SPR-330 Category:

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    SPR-330_Tau-Preformed-Fibrils-Protein-IHC-1.png
    Comparison of AT8 (pSer202/pThr205) tau inclusions in P301L mice injected with K18 PFFs and negative control.TEM of recombinant Tau (K18), P301L mutant Pre-formed Fibrils (PFFs)TEM of recombinant Tau (K18), P301L mutant Pre-formed Fibrils (PFFs)Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau Pre-formed fibrils (SPR-330). Tau Pre-formed fibrils (SPR-330) seed the formation of new tau fibrils when combined with tau monomers (SPR-327)SDS-PAGE of ~15 kDa Human Tau Protein K18/P301L Pre-formed Fibrils (SPR-330)