A calcium channel is a type of transmembrane ion channel that is permeable to calcium ions. These channels can be gated by either voltage or ligand binding.
Voltage-gated calcium channels are opened by depolarization membrane potentials, thereby allowing an influx of calcium ions from outside the cell. There are five types of voltage-gated calcium channels: L-type, P-type, N-type, R-type, and T-type.
Ligand-gated calcium channels are opened by the binding of a ligand such as a neurotransmitter to the receptor. Types of ligand-gated calcium channels include IP3 receptors, ryanodine receptors, and two-pore channels.
Calcium channel blockers, also known as calcium channel antagonists, prevent the flow of calcium ions through the channel. Dihydropyridine calcium channels blockers are used clinically as a medication to treat hypertension. Other calcium channel blockers can be used to control heart rate, and reduce chest pain.
Ion channel research requires a great diversity of life science products. We are dedicated to developing cutting edge research products to aid in the study of calcium channels, including monoclonal antibodies, polyclonal antibodies, antibody conjugates, immunoassays, and small molecule inhibitors.View all Calcium Channels Products