Cyclic Nucleotide-Gated Ion Channels

Cyclic nucleotide-gated ion channels are transmembrane proteins that allow the non-selective passage of cations through the channel upon activation by cyclic nucleotides. These channels are found in both animals and plants, and across various tissue and cell types including photoreceptors in the retina, and olfactory receptor neurons.

Cyclic nucleotide-gated ion channels are activated by the binding of four cyclic nucleotides such as cyclic AMP (cAMP) or cyclic GMP (cGMP). Activation of these channels can result in either depolarization or hyperpolarization of the cell.

Cyclic nucleotide-gated ion channels are composed of a pore and four subunits (alpha or beta subunits).

There are two subtypes of cyclic nucleotide-gated ion channels: cyclic nucleotide-gated (CNG) ion channels, and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

There are six types of CNG channels each composed of different subunits: CNGA1, CNGA2, CNGA3, CNGA4, CNGB1, and CNGB2.

A hyperpolarization-activated cyclic nucleotide-gated channel is a subtype that is gated by hyperpolarization of the cell membrane. They are expressed in the cells of the heart and brain where they control the rhythmic activity of cell groups. Cyclic nucleotide binding enhances channel activity by shifting the activation curve of the channels to more positive voltages. There are four HCN channels: HCN1, HCN2, HCN3, and HCN4.

Ion channel research requires a great diversity of life science products. We are dedicated to developing cutting edge research products to aid in the study of Cyclic nucleotide-gated channels, including monoclonal antibodies, polyclonal antibodies, antibody conjugates, immunoassays, and small molecule inhibitors.

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