What is ALS disease?
Amyotrophic Lateral Sclerosis (ALS), often called Lou Gehrig’s disease or motor neuron disease, is a progressive neurological disease. It rapidly results in the death of motor neurons in both the brain and spinal cord. Without the ability to transmit signals to muscles via motor neurons, individuals are unable to perform any voluntary movement and the muscles begin to deteriorate.
Although the cause of ALS remains unknown, mutations in the gene encoding superoxide dismutase 1 (SOD1) have been found to be associated with familial cases of ALS.
Mutations in Transient receptor potential cation channel subfamily M member 7 (TRPM7) have also been associated with increased susceptibility to Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1).
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